Acceleration of Socket Healing by Using Placental Collagen with BDNF: Radiological and Histological Studies

Background: Alveolar bone regeneration can be guided by the application of a collagen protein coupled with neuroinductive protein, following tooth extraction.

Aim of the study: The present study was designed to evaluate the radiologic, histologic and histomorphometric aspects of socket healing in extraction site received placental collagen with brain-derived neurotrophic factor (BDNF), compared with control site that healed spontaneously.

Materials and Method: Twelfth Sprague-Dawley male rats were subjected for a surgical tooth extraction of upper central teeth of both sides. The right side be the control one as the socket healed spontaneously. while left side be the experimental site, as tooth socket treated with 1μL of placental collagen with 1μL of BDNF. The rats were scarified at 2 and 4 weeks post extraction. Socket healing was examined radiographically and histologically.

Results: Experimental site illustrates trabecular bones formation between the peripheral and central regions of the sockets at 2 weeks and increment of bone formation was observed, filled most of socket at 4 weeks with reepithelization recognized at the surface. Radiographical view shows radiopaque that comprising 50% to 74% of the overall area of the socket and was assigned a score of 3 with a high p value in comparisum to control.

Conclusion: The present study, high lighted on osseo-inductive effect of the local application of placental collagen with BDNF in socket healing.