Combination Use of Aloe Vera and VEGF Promotes Osseointegration and Stability of Titanium Implants

Background: Aloe vera was used to enhance defense mechanisms, and it has a variety of components that affected on periodontal healing and other oral condition. It was used also around dental implants to control inflammation from bacteria contamination. Vascular endothelial growth factor (VEGF) is of particular interest because of its ability to induce neovascularization (angiogenesis), VEGF also acts to recruit and activate osteoclasts as well as stimulate osteoblast chemotaxis, differentiation, and matrix mineralization.

Aim of study: The objective of this research was to illustrate the biological actions of topical application of aloe vera and growth factor VEGF on implant tissue contact surface which is involved in osseointegration.

Materials and Method: Commercially pure Titanium (cpTi) implants with aloe vera/and VEGF, were placed in the tibia of (24) New Zealand white rabbits, Mechanical test (torque removal test) was performed as an indicator for the presence of osseointegration and bone implant contact (BIC) measurement as a test for the property of bone-implant interface.

Histological investigation was performed on all the implants of both control and experimental groups at (1, 2, and 6weeks) healing intervals.

Results: Findings illustrated that removal torque mean and BIC values in experimental implant showed high value in comparison to control. Histological results show an early bone deposition and early maturation in combination group.

Conclusions: Bone formation &maturation was accelerated by adding biological materials and using a combination of Aloe Vera and VEGF is a powerful tool for enhancement of osseointegration.