Aziz TA, Marouf BH, Mahmood NMA, Hussain SA. Anti-inflammatory activity of benfotiamine in adjuvant-induced arthritis and cotton pellet-induced granuloma models of inflammation in rats. Glob J Pharmacol. 2011;5(2):86-91.
Abstract
Although the currently used anti-inflammatory agents strongly alleviate inflammatory diseases, their use in humans is strictly limited because of their severe adverse effects, including gastric ulcers and dysfunction, and looking for safer alternatives can be justified. The present study was designed to evaluate the possible anti-inflammatory effect of benfotiamine in experimental animal models of adjuvant-induced arthritis (AIA) and granulomatous inflammation. Thirty-two rats allocated into 4 groups were used to evaluate the effect of orally administered 300 mg/kg b. wt. benfotiamine in the AIA model, while 18 rats were used to evaluate the effect of the same dose of benfotiamine in the cotton pellet-induced granuloma model; all results were compared with those of 2 mg/kg dexamethasone. The result showed that benfotiamine in both models significantly attenuates inflammatory processes but still does not match that produced by dexamethasone. In conclusion, benfotiamine modulates the inflammatory response in both AIA and cotton pellet-induced granuloma models in rats.
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