Hematopoietic toxicity of Loranthus europeaus chloroform extract: In vivo study

Hasan AF, Numan IT, Al-Sammarrae KW, Hussain SA. Hematopoietic toxicity of Loranthus europeaus chloroform extract: an in vivo study. Pharm Glob. 2011;7(2):1-4.

Abstract

Methanolic extracts of some mistletoe species exhibited moderate cytotoxicity against cultured human tumor cell lines in vitro. However, the genetic toxicity of Loranthus europaeus is not well defined. In this study, a chloroform extract of L. europaeus was prepared and used for the investigation of the genotoxic effects of different doses, administered orally, on the bone marrow and peripheral blood cells of mice. Results showed that treatment with a large dose of the extract decreased the mitotic index and increased chromosomal aberration compared to vehicle-treated animals and was comparable to that produced by methotrexate. The high dose of the extract also significantly decreases the total and differential WBC count compared to both the lower dose and methotrexate. In conclusion, the chloroform extract of L. europaeus shows pronounced gene toxicity with increasing doses when administered orally to mice.

https://www.researchgate.net/publication/216868796_Hematopoietic_toxicity_of_Loranthus_europeaus_chloroform_extract_In_vivo_study