Alhasani NR, Al-Bustani AI, Hussain SA, Ghareeb MM. Clinical efficacy of locally injected calcitriol in orthodontic tooth movement. Int J Pharmacy Pharm Sci. 2011;3:139-143.
Abstract
Orthodontic treatment has two major problems: being a lengthy and costly procedure. The present study was designed to evaluate the clinical efficacy of locally injected vitamin D 3 (calcitriol) in accelerating orthodontic tooth movement (OTM) and reducing treatment time and cost in humans. The study was performed on 15 Iraqi adult orthodontic patients within the age range of 17–28 years. They were randomly allocated into three groups, each of five patients, and treated with either 15 pg, 25 pg, or 40 pg/0.2 ml calcitriol diluted with 10% dimethylsulfoxide (DMSO). The maxillary arch of every patient was divided into the control (right) and experimental (left) sides. In addition to force application, the right canine received 0.2 ml of DMSO injections, while the left canine received calcitriol injections. The follow-up period for every patient included five visits at one-week intervals, during which they received two injections three times and were evaluated for OTM, GCf collection and radiographic examination. Statistically nonsignificant differences were reported for OTM between the control and experimental sides and among the three groups. However, on a clinical efficacy basis, the dose of 25 pg calcitriol produced about a 51% faster rate of experimental canine movement compared to the control, while each of the 15 pg and 40 pg doses resulted in about 10% accelerated OTM. Furthermore, the periapical radiographs showed no damaging effect of calcitriol on the surrounding tissues. In conclusion, for the first time, we reported that locally injected calcitriol, in a dose-dependent pattern, is clinically and cost-effective in humans.
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