Ruaa Fadhil Abbas, Saad A. Hussain, Amal Ajaweed Sulaiman. Radical scavenging activity of telmisartan in nitrite-induced hemoglobin oxidation: In vivo study. World J Pharm Res 2017; 6(3):161-169.
Abstract
A large number of therapeutic and environmental agents may cause methemoglobinemia, like nitrite. Several free radical species are generated during the course of nitrite-induced methemoglobin formation. Telmisartan, a highly selective antagonist of Angiotensin II type 1 (AT1) receptors, is widely used in the treatment of hypertension and congestive heart failure. The study was designed to evaluate the expected protective activity of telmisartan against nitrite-induced hemoglobin oxidation. 18 male rats were randomly allocated into 3 groups. Rats in Group I served as controls and were given distilled water. In group II (long term exposure), telmisartan (10 mg/kg) was given once daily orally for 7 days; on the seventh day, sodium nitrite (100 mg/kg body weight) was given orally. In group III, telmisartan (10 mg/kg) was given as a single oral dose; thereafter, a toxic dose of sodium nitrite (100 mg/kg) was given orally. Blood samples were obtained for the measurement of methemoglobin levels for each group. The results showed that telmisartan significantly decreased nitrite-induced methemoglobin formation compared with control. Telmisartan attenuates sodium nitrite-induced hemoglobin oxidation and maintains the integrity of red blood cells through free radical scavenging activity.
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