Haithem R. Mohammed, Kadhim A. Kadhim, Hasan M. Alkutubi, Abbas M. Rahmah, Ban H. Khalaf, Saad A. Hussain, Hayder A. Fawzi. Correlation between ABO blood groups with insulin resistance in type II diabetes mellitus patients using Metformin. Int. J. Res. Pharm. Sci. 2018; 9(3):893-900. DOI: https://doi.org/10.26452/ijrps.v9i3.1592
Abstract
The aim of the present study is to investigate the relationship between ABO blood group, glycaemic control and insulin resistance in type II DM using metformin therapy. Fifty-five patients newly diagnosed with type 2 diabetes mellitus were collected in the diabetic centre Al-Husseini hospital by the specialist physician, according to the American Association of Diabetes, from December 2015 to May 2016. ABO blood groups based on insulin resistance, blood glucose and body mass index were determined and correlated with each other. AB blood group had more reduction in FBG, HbA1c %, BMI (-38.6,-.22.8,-55.1,-4.3, respectively) by effect metformin treatment after three months from other blood groups. The correlation of ABO blood groups based on insulin resistance with FBG and HbA1c% showed the AB blood group had a greater reduction in glycemic control (FBG, and %) after metformin treatment. The present study showed that different ABO blood groups had a different effect on glycemic control and insulin resistance about metformin treatment in newly diagnosed type 2 diabetes after three months. Also, AB blood group has a greater association with response to metformin treatment compared with other blood groups.
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