The anti-inflammatory activity of azilsartan in animal models of experimentally-induced chronic and granulomatous inflammation

Wael W. Mustafa, Samer Shukur, Saad A. Hussain, Naza MA Mahmood. The anti-inflammatory activity of azilsartan in animal models of experimentally-induced chronic and granulomatous inflammation. Int. J. Res. Pharm. Sci. 2018; 9(4):1162-1168. DOI: https://doi.org/10.26452/ijrps.v9i4.1649

Abstract

It is well documented that blockade of angiotensin II type 1 receptors may interfere with the progression of inflammatory processes. The present study aims to evaluate the dose-response relationship of the anti-inflammatory activity of azilsartan in rat models of chronic and granulomatous inflammation. The study includes two parts: First part: 42 rats were allocated into 7 groups, each containing six rats, to evaluate the anti-inflammatory activity of different doses of azilsartan in a rat model of formalin-induced chronic inflammation. Second part: 42 rats were allocated as the first group to evaluate the anti-inflammatory activity of azilsartan in a rat model of cotton pellet-induced granuloma. Azilsartan in a dose-dependent pattern (0.125, 0.25, 0.5, 1.0, and 2.0 mg/kg) significantly attenuated inflammation in both rat models utilized in the study, with the maximum effect achieved at 1.0 mg/kg, which is comparable to that reported for dexamethasone and has relative linearity within the lowest dose range. In conclusion, azilsartan decreased formalin-induced chronic inflammation and cotton-pellet induced granuloma in rats in a dose-dependent pattern. Therefore, it may be considered a potential candidate for treating chronic inflammatory conditions in humans.

Professor Saad Abdulrahman Hussain

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