Oral flora and functional dysbiosis of cleft lip and palate patients: A scoping review

Abstract
Aims: This scoping review aimed to conduct an assessment of the current literature
on specific ecological changes in the oral microbiota of individuals living
with cleft lip and/or palate.
Methods: All studies that assess oral microbiota and ecological changes distinct
of individuals living with cleft lip and/or palate were included. Ovid MEDLINE
and EMBASE databases were used, using planned search keywords. Included
articleswere grouped into cohort, cross-sectional, case-control, and retrospective
reviews.
Results: A total of 164 eligible title articles were recognized. Of these, 32 fulltext
studies were included in the present review. All the included articles were
published between 1992 and 2022. These studies were two retrospective studies,
two review studies, and the remaining (n = 28) were observational studies.
Conclusion: The oral flora of cleft lip and/or palate patients has been shown
in scientific studies to have an increased frequency of potentially pathogenic
fungal and bacterial colonization, particularly Candida species, Staphylococcus
aureus, Lactobacili and Streptococci mutans. Thismay influence oral diseases and
post-operative repair complications, potentially necessitating further surgical
intervention.
KEYWORDS
cleft lip and palate, oral candidiasis, oral microbiology
DOI: 10.1111/scd.12872

Nadia Bassim Al-Ansari

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