Khaleel NY, Abdulrasool AA, Ghareeb MM, Hussain SA. SOLUBILITY AND DISSOLUTION IMPROVEMENT OF KETOPROFEN BY SOLID DISPERSION IN POLYMER AND SURFACTANT USING SOLVENT EVAPORATION METHOD. Int J Pharm Pharm Sci. 2011;3(4):431-435.
Abstract
Ketoprofen is a propionic acid derivative non‐steroidal anti‐inflammatory drug. It is widely used in the management and treatment of patients with rheumatic disease, but its poor water solubility can give rise to formulation problems and reduce its therapeutic efficiency and bioavailability. The present project was designed to improve solubility and dissolution of ketoprofen. Various solid dispersions formulas of ketoprofen were prepared by solvent evaporation method using mannitol, Urea, PVP K30, and Tween 80 as carriers to enhance solubility of compound. These formulations were evaluated for drug content, phase solubility, and in vitro dissolution. Evaluation by Deferential Scanning Calorimetry (DSC) and Fourier
Transformer Infra Red (FTIR) revealed no chemical interaction between the drug and its carriers. All formulas showed marked improvement in solubility behavior and drug release in the following order PVP K‐30> urea>mannitol. Formulation (F12) containing ketoprofen: PVP K‐30: Tween 80 ratio of 1:3:1 showed best release (95.0%) compared to 23.20 % for the pure drug at 5 minutes. In conclusion, solid dispersion of ketoprofen in polymer with surfactant properties (formulation‐F12) can be utilized to improve solubility and release of ketoprofen oral solid dosage form.
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